MAO-B-IN-49

Overview

MAO-B-IN-49 is a selective and reversible MAO-B inhibitor ( IC 50 of 1 nM for human MAO-B ). MAO-B-IN-49 shows much higher selectivity for MAO-B than for MAO-A ( IC 50 = 633.9 μM). MAO-B-IN-49 can reduce ROS production induced by Lipopolysaccharides ( HY-D1056 ) (LPS) in HT22 cells. MAO-B-IN-49 demonstrates substantial neuroprotective properties and significantly improves motor dysfunction in MPTP ( HY-W114750 )-induced mouse models of Parkinson’s disease (PD). MAO-B-IN-49 can be used for the study of PD.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Monoamine Oxidase | Products > Signaling Pathways > Reactive Oxygen Species (ROS)

Product Information

• Catalog No.: HY-178352
• CAS No.: 3098883-91-8
• Molecular Formula: C19H20F2N2O3
• Molecular Weight: 362.37
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source