CAII/VII-IN-1

Overview

CAII/VII-IN-1 is an orally active hCA II ( K I = 12.3 nM), and hCA VII ( K I = 22.6 nM) inhibitor, showing no significant activity against hCA I. CAII/VII-IN-1 shows excellent neuroprotective activity in vivo Pilocarpine ( HY-B0726A )-induced seizure model. CAII/VII-IN-1 can upregulate KCC2 and inhibit mTOR , exerting neuroprotective effects. CAII/VII-IN-1 does not show any significant neurotoxic effects or alterations in liver and kidney function. CAII/VII-IN-1 can be used for the study of epilepsy.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Carbonic Anhydrase | Products > Signaling Pathways > NKCC | Products > Signaling Pathways > mTOR

Product Information

• Catalog No.: HY-178362
• CAS No.: 3085155-69-4
• Molecular Formula: C27H23ClN8O5S2
• Molecular Weight: 639.11
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source