RIPK1-IN-34

Overview

RIPK1-IN-34 is a selective, brain-penetrant RIPK1 inhibitor ( IC 50 = 126.70 nM) with almost no inhibitory effect on RIPK3 ( IC 50 ＞ 10, 000 nM). RIPK1-IN-34 offers substantial neuroprotection by inhibiting the phosphorylation of RIPK1 , RIPK3 , and mixed lineage kinase domain-like pseudokinase (MLKL) within the necroptosis pathway. RIPK1-IN-34 shows the neuroprotective effect in a rat middle cerebral artery occlusion (MCAO) model. RIPK1-IN-34 can be used for the study of anti-acute ischemic stroke (AIS).

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > RIP kinase | Products > Signaling Pathways > Mixed Lineage Kinase | Products > Signaling Pathways > Necroptosis

Product Information

• Catalog No.: HY-178464
• CAS No.: 3065634-19-4
• Molecular Formula: C28H25N7O2
• Molecular Weight: 491.54
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source