FABP4/5-IN-6

Overview

FABP4/5-IN-6 is an orally active, potent FABP4/5 inhibitor ( Ki = 0.41/2.53 μM), showing low selectivity over FABP3 ( Ki = 59.72 μM). FABP4/5-IN-6 inhibits the secretion of MCP-1 and IL-6 in Lipopolysaccharides ( HY-D1056 ) (LPS)-induced THP-1 macrophage. FABP4/5-IN-6 exhibits significant anti-inflammatory effects and attenuates LPS-induced liver injury. FABP4/5-IN-6 has low hERG inhibition ( LD 50 > 2000 mg/kg). FABP4/5-IN-6 can be used for the study of Inflammation-related diseases.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > FABP | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-178471
• CAS No.: 2975215-64-4
• Molecular Formula: C21H16Cl2FNO3
• Molecular Weight: 420.26
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source