Mollicellin K is a depsidone that can be isolated from the fungus Chaetomium brasiliense . Mollicellin K exhibits antimicrobial activity against Myobacterium tuberculosis , antimalarial activity ( IC 50 = 1.2 μM) against Plasmodium falciparum as well as antifungal property ( IC 50 = 1.2 μM) against Candida albicans . Mollicellin K is cytotoxic against KB ( IC 50 = 1.9 μM), BC1 ( IC 50 = 6.8 μM), NCI-H187 ( IC 50 = 0.35 μM), and five cholangiocarcinoma cell lines. Mollicellin K also has an MIC of 12.5 μM for tuberculosis.
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