Cot-IN-4

Overview

Cot-IN-4 (compound 32) is a potent cancer osaka thyroid (COT) kinase inhibitor with an IC 50 of 6 nM. Cot-IN-4 inhibits the phosphorylation of ERK (IC 50 : 60 nM) and inhibits TNFα release (IC 50 : 60 nM). Cot-IN-4 also inhibits the formation of the pro-inflammatory cytokine IL-1β (IC 50 : 0.2 μM) in Uric acid ( HY-B2130 )-stimulated macrophages. Cot-IN-4 can be used for the study of inflammatory diseases.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > MAP3K | Products > Signaling Pathways > ERK | Products > Signaling Pathways > TNF Receptor | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-178726
• CAS No.: 1984784-10-2
• Molecular Formula: C30H28N8O
• Molecular Weight: 516.60
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source