GC-072

Overview

GC-072 is an orally active, 4-oxoquinolizine antibiotic that selectively inhibits bacterial DNA gyrase and Topo IV enzymes . GC-072 does not inhibit human topoisomerases I and II. GC-072 demonstrates strong antimicrobial activity against various bacterial strains, including Gram-positive, Gram-negative, and resistant bacteria. GC-072 also exhibits bactericidal activity against Burkholderia pseudomallei both extracellularly and intracellularly, leading to dose-dependent survival in mice exposed to lethal inhalational models of B. pseudomallei infection . GC-072 can be used for the research of melioidosis.

Application

Products | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Infection | Products > Signaling Pathways > Antibiotic | Products > Signaling Pathways > Bacterial | Products > Signaling Pathways > Topoisomerase | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-178738
• CAS No.: 1371629-36-5
• Molecular Formula: C20H16F2N2O3
• Molecular Weight: 370.35
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source