PGK1-IN-1

Overview

PGK1-IN-1 (Compound 6e) is a potent and selective PGK1 inhibitor ( IC 50 : 33 nM). PGK1-IN-1 inhibits PGK1-mediated glycolytic metabolism and reduces glucose consumption/lactate production. PGK1-IN-1 enhances Nrf2 accumulation and HO-1 expression, and suppresses the transcription and protein levels of the inflammatory cytokines IL-1β and IL-6 . PGK1-IN-1 ameliorates Dextran sulfate sodium (DSS) ( HY-116282C )-induced experimental colitis in mice. PGK1-IN-1 can be used for research of inflammatory bowel disease (IBD).

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Phosphoglycerate Kinase (PGK) | Products > Signaling Pathways > Keap1-Nrf2 | Products > Signaling Pathways > Heme Oxygenase (HO) | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-178761
• CAS No.: 3093312-81-0
• Molecular Formula: C22H28N6O3
• Molecular Weight: 424.50
• Purity: 99.78%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source