SIRT2-IN-18

Overview

SIRT2-IN-18 (Compound 8) is a SIRT2 inhibitor with IC 50 s of 5.3 and 12.3 μM for Sm SIRT2 and hSIRT2, respectively. SIRT2-IN-18 shows potent antischistosomal activities against both Liberian and Puerto Rican strains of Schistosoma mansoni and reduces schistosomula and adult worm pair viability, pairing, and egg production, with low cytotoxicity in mammalian cells. SIRT2-IN-18 increases histone H3 hyperacetylation and induces cytochrome c-mediated apoptosis .

Application

Products | Products > Disease Areas > Infection | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Infection | Products > Signaling Pathways > Sirtuin | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-178773
• CAS No.: 858032-59-4
• Molecular Formula: C21H12N2O3
• Molecular Weight: 340.33
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source