BCL6-760

Overview

BCL6-760 is an orally active BCL-6 PROTAC degrader with an EC 50 of 0.8 nM. BCL6-760 only degrades BCL6 and has no effect on other CRBN substrates. BCL6-760 demonstrates significant efficacy in the orthotopic xenograft mouse model of OCI-LY-1 tumors. BCL6-760 can be used in the research of diffuse Large B-cell Lymphoma (DLBCL) (Pink: BCL-6 ligand ( HY-179317 ); Blue: CRBN ligand ( HY-179305 ); Black: Linker). (Pink: BCL6 ligand ( HY-179317 ); Blue: no E3 ligase ligand; Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > BCL6

Product Information

• Catalog No.: HY-178777
• CAS No.: 3084696-50-1
• Molecular Formula: C36H43ClN10O4
• Molecular Weight: 715.24
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source