STING-IN-17

Overview

STING-IN-17 (compound 10a) is an orally active STING (human STING IC 50 = 29 nM, mouse STING IC 50 = 15 nM) inhibitor. STING-IN-17 can inhibit the phosphorylation of STING , TBK1 and IRF3. STING-IN-17 dose dependently inhibits the mRNA expression of IP10, IFNB1 and ISG56. STING-IN-17 can reduce ROS and inhibit the expression of cleaved-PARP/caspase-3 . STING-IN-17 can improve kidney function. STING-IN-17 can be used for research on inflammatory conditions such as acute kidney injury.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > IFNAR | Products > Signaling Pathways > PARP | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > STING | Products > Signaling Pathways > IKK

Product Information

• Catalog No.: HY-178951
• CAS No.: 3069635-58-8
• Molecular Formula: C30H26F4N4O2
• Molecular Weight: 550.55
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source