Nav1.2-IN-2 is a Nav1.2 inhibitor with a human IC 50 of 0.18 μM. Nav1.2-IN-2 preferentially binds to the inactivated state of Nav1.2, reduces window current, suppresses neuronal depolarization and action potential generation. Nav1.2-IN-2 suppresses Veratridine ( HY-N6691 )-induced Ca 2+ influx. Nav1.2-IN-2 can be used for the research of epilepsy.
Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Epilepsy | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Sodium Channel | Products > Signaling Pathways > Calcium Channel
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