SHP2-IN-45

Overview

SHP2-IN-45 (Compound 6) is a potent, highly selective, and orally active SHP2 allosteric inhibitor. SHP2-IN-45 significantly reduces the expressions of IL-6 , TNF-α , IL-1β , and iNOS . SHP2-IN-45 inhibits the polarization of M1-type macrophages. SHP2-IN-45 can inhibit the NF-κB pathway. SHP2-IN-45 can be used in the research of sepsis and acute lung injury.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > TNF Receptor | Products > Signaling Pathways > SHP2 | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > NO Synthase | Products > Signaling Pathways > NF-κB

Product Information

• Catalog No.: HY-178983
• CAS No.: 2949435-53-2
• Molecular Formula: C20H21ClN6S
• Molecular Weight: 412.94
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source