PSP-0119

Overview

PSP-0119 is a highly efficient and effective PROTAC degrader targeting IRAK4 ( IC 50 = 2.83 nM). PSP-0119 can inhibit IRAK4 kinase activity, NF-κβ activity, and IL-1β-induced IRAK4 phosphorylation. PSP-0119 degrades IRAK4 in FLT3-mutant AML cell lines, sparing FLT3-wild-type AML cells, FLT3-wild-type samples, and normal bone marrow. PSP-0119 downregulates alpha-enolase ( eNOS ) of MOLM-13 cells. PSP-0119 can be used for the study of Acute Myeloid Leukemia (AML). (Pink: IRAK4 ligand ( HY-179095 ); Blue: Cereblon ligand ( HY-A0003 ); Black: linker ( HY-W008820 )).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Enolase | Products > Signaling Pathways > IRAK

Product Information

• Catalog No.: HY-179094
• CAS No.: 3104855-98-0
• Molecular Formula: C38H39N9O7
• Molecular Weight: 733.77
• Purity: 98.65%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (3.41 mM); Clear solution
• Availability: In-stock

Source

Original product source