COX-2-IN-60

Overview

COX-2-IN-60 is a potent, orally active, and selective COX-2 inhibitor with an IC 50 of 0.06 μM. COX-2-IN-60 exhibits ~100-fold selectivity over COX-1 ( IC 50 = 5.93 ). COX-2-IN-60 reduces oxidative stress and neuroinflammatory cytokines, and effectively counteracts epileptogenesis. COX-2-IN-60 exhibits significant anticonvulsant effects and protects against hippocampal injury by suppressing oxidative stress (reducing MDA and NO ), pro-inflammatory signaling (reducing TNF-α and IL-6 ), and glial activationin in the Pilocarpine ( HY-B0726A )-induced seizure mouse model. COX-2-IN-60 can be used for the research on neuroinflammatory and epilepsy.

Application

Products | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > COX | Products > Signaling Pathways > TNF Receptor | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-179142
• CAS No.: 3073624-74-2
• Molecular Formula: C17H15BrN2O4
• Molecular Weight: 391.22
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source