LIQ1

Overview

LIQ1, a flavonoid derivative, is a potent Pyruvate kinase M2 ( PKM2 ) allosteric inhibitor ( IC 50 = 0.39 μM; K d = 4.5 μM) targeting Arg43 within the polyarginine pocket. LIQ1 exhibits efficacy in a mouse model of LPS ( HY-D1056 )-induced endotoxemia, preventing the nuclear translocation of PKM2 and inhibiting its binding to HIF-1α , thereby suppressing IL-1β transcription. LIQ1 can be used for the research of endotoxemia [1] .

Application

Products | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Pyruvate Kinase | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-179371
• CAS No.: 2606032-80-6
• Molecular Formula: C16H12O5
• Molecular Weight: 284.26
• Purity: 97.40%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (8.79 mM); Clear solution
• Availability: In-stock

Source

Original product source