XRF-1021

Overview

XRF-1021 is an orally active HIPK2 inhibitor ( IC 50 = 0.18 μM). XRF-1021 reduces the expression of fibrotic markers in TGF-β1 stimulated NRK-49F and HK-2 cells, including Fibronectin, Collagen I and α-SMA. XRF-1021 blocks TGF-β , NF-κB , p53 , Wnt/β-catenin , and Notch signaling. XRF-1021 reduces renal injury and fibrosis in vivo . XRF-1021 can be used for the research of chronic kidney disease.

Application

Products | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Renal Disease | Products > Disease Areas > Chronic Kidney Disease | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Wnt | Products > Signaling Pathways > β-catenin | Products > Signaling Pathways > MDM-2/p53 | Products > Signaling Pathways > Notch | Products > Signaling Pathways > DYRK | Products > Signaling Pathways > TGF-beta/Smad

Product Information

• Catalog No.: HY-179378
• CAS No.: 2968523-32-0
• Molecular Formula: C21H21FN8
• Molecular Weight: 404.44
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source