Cannabitwinol

Overview

Cannabitwinol is a selective thermosensitive TRP modulator and NF-κB inhibitor. Cannabitwinol inhibits TNFα-induced NF-κB -driven transcription and TNFα-induced IL-8 release, and exhibits anti-inflammatory and antioxidant activities. Cannabitwinol shows selectivity for cold-activated TRP channels, activating TRPA1 ( EC 50 = 3.0 μM) and antagonizing TRPM8 ( IC 50 = 3.9 μM), but has no significant affinity for heat-activated TRP channels such as TRPV1 and TRPV2. Cannabitwinol can be used in research related to inflammatory skin diseases, cold allodynia, and hyperalgesia.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Pain | Products > Disease Areas > Skin Inflammation | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > TRP Channel | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-179432
• CAS No.: 2699950-81-5
• Molecular Formula: C43H60O4
• Molecular Weight: 640.93
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source