CHF-6333 xinafoate is a neutrophil elastase ( NE ) inhibitor ( IC 50 = 0.21 nM; K D = 0.16 nM). CHF6333 xinafoate retains its activity in both human ( IC 50 = 0.22 nM) and rat ( IC 50 = 3.63 nM) proteases. CHF6333 xinafoate exhibits inhibitory activity against Proteinase 3 ( IC 50 = 22 nM). CHF-6333 xinafoate can be used for the study of bronchiectasis (BE).
Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Respiratory Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Elastase
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