F3288-0031

Overview

F3288-0031 is a brain-penetrant norepinephrine transporter ( NET ) allosteric inhibitor with inhibitory rates of 73.5% at 20 μM. F3288-0031 binds within the inner vestibule of NET , stabilizing the inward-open state and has a preferential NET / SERT inhibition with pIC 50 = 5.9. F3288-0031 shows no detectable off-target functional activity in vitro. F3288-0031 demonstrates robust antidepressant-like efficacy in vivo without confounding locomotor effects, F3288-0031 can be used for depressive disorder and related neuropsychiatric conditions.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Depression | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Monoamine Transporter

Product Information

• Catalog No.: HY-179568
• CAS No.: 926493-93-8
• Molecular Formula: C24H32N2O3
• Molecular Weight: 396.52
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source