EL244

Overview

EL244 is a dua Autotaxin ( ATX ) ( IC 50 = 50 nM) inhibitor and PPARγ ( IC 50 = 1.3 μM; K d = 1.3 μM) agonist. EL244 demonstrates low cytotoxicity in human HepG2 cells ( EC 50 = 81.2 μM) with minimal inhibition of the cardiac hERG potassium channel (12% at 25 μM). EL244 significantly reduces pulmonary Lysophosphatidic Acid (LPA) levels, attenuates fibrosis, and restores respiratory function with limited systemic absorption in vivo. EL244 can be used for idiopathic pulmonary fibrosis and interstitial lung disease (ILD) research.

Application

Products | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Pulmonary Disease | Products > Disease Areas > Lung Fibrosis | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > PPAR | Products > Signaling Pathways > Phosphodiesterase (PDE)

Product Information

• Catalog No.: HY-179580
• CAS No.: 3047548-70-6
• Molecular Formula: C25H26Cl2N2O5S
• Molecular Weight: 537.46
• Purity: 99.55%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source