GSTO1-IN-6

Overview

GSTO1-IN-6 is an allosteric and covalent GSTO1 inhibitor with an IC 50 of 457 nM. GSTO1-IN-6 markedly reduces Lipopolysaccharides (LPS) ( HY-D1056 )-induced IL-1β (IC 50 of 1.9 μM) and IL-18 (IC 50 of 10. μM) secretion in human monocyte-derived macrophages. GSTO1-IN-6 covalently modifies GSTO1-Cys32, inducing conformational changes and protein destabilization. GSTO1-IN-6 can be used for the research of inflammatory diseases.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Glutathione S-transferase | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-179635
• CAS No.: 3114128-67-2
• Molecular Formula: C16H14F3N3OS
• Molecular Weight: 353.36
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source