CIAC101

Overview

CIAC101 is a potent and brain-penetrant TLR4 antagonist with an IC 50 of 17.0 nM in NO assay. CIAC101 blocks Lipopolysaccharides ( HY-D1056 ) (LPS)-induced NF-κB activation and reduces the expression of pro-inflammatory mediators ( iNOS , IL-1β , TNF-α , and IL-6 ). CIAC101 robust antineuroinflammatory activity with efficacy against drug-evoked neurobehavioral adaptations. CIAC101 can be used for the research of addiction and neurological disease .

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Toll-like Receptor (TLR) | Products > Signaling Pathways > NO Synthase | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > TNF Receptor | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-179646
• CAS No.: 3122563-80-5
• Molecular Formula: C24H29NO4
• Molecular Weight: 395.49
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source