ZG-2686

Overview

ZG-2686 is a potent and selective HIF-2α agonist with an EC 50 of 0.25 µM. ZG-2686 exhibits selectivity over PHD2 . ZG-2686 binds to a specific internal cavity of HIF-2α, forming hydrogen bonds via structural water molecules, which stabilizes the HIF-2α/ β heterodimer and enhances transcriptional activity. ZG-2686 synergizes with Vadadustat ( HY-101277 ) to upregulate HIF-2α-dependent EPO gene expression both in vitro and in vivo. ZG-2686 can be used for the research of renal anemia.

Application

Products | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Renal Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Metabolic Disease | Products > Research Areas > Endocrinology | Products > Signaling Pathways > HIF/HIF Prolyl-Hydroxylase

Product Information

• Catalog No.: HY-179647
• CAS No.: 1795110-22-3
• Molecular Formula: C13H9BrN4O
• Molecular Weight: 317.14
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source