sALT629 is an orally active antitubercular agent with potent intramacrophage activity ( EC 50 = 1.5 μM). sALT629 shows broad-spectrum anti- Mycobacterium tuberculosis (Mtb) activities across four carbon sources, equipotent efficacy against drug-resistant Mtb, and activity against both slow-replicating and nonreplicating Mtb. sALT629 exhibits synergistic activity when combined with oxazolidinone drugs, such as Linezolid ( HY-10394 ) and Sutezolid ( HY-10392 ). sALT629 can be used for the research of tuberculosis.
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