PCC0105005

Overview

PCC0105005 is a dual-target CGRP Receptor antagonist ( IC 50 = 1.01 nM) and a partial agonist of 5-HT1F Receptor ( EC 50 = 77.91 nM). PCC0105005 shows significant efficacy in the rat model of migraine. PCC0105005 significantly reduces the expression of CGRP and c-Fos proteins, and inhibits the phosphorylation levels of ERK and CREB. PCC0105005 can be used for research on migraine.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Pain | Products > Disease Areas > Migraine | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Epigenetic Reader Domain | Products > Signaling Pathways > CGRP Receptor | Products > Signaling Pathways > 5-HT Receptor | Products > Signaling Pathways > ERK

Product Information

• Catalog No.: HY-179684
• CAS No.: 2921670-99-5
• Molecular Formula: C51H63N11O4
• Molecular Weight: 894.12
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source