Cbz-QFR-kbt is a ketone-based benzothiazole ketone inhibitor of TMPRSS2 , with an IC 50 value of 0.42 nM. Cbz-QFR-kbt also has inhibitory activity against Matriptase , Hepsin , HGFA , and Factor Xa , with IC 50 values of 1, 1.3, 85, and 85 nM respectively. Cbz-QFR-kbt shows significant inhibitory effects against SARS-CoV-2 and H1N1 ( IC 50 = 60 nM). Cbz-QFR-kbt can be used in antiviral research.
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