GSK3β-IN-4

Overview

GSK3β-IN-4 is a selective, potent, orally active and brain-penetrant ATP-competitive GSK3β inhibitor with an IC 50 of 0.37 nM. GSK3β-IN-4 shows an IC 50 of 2.75 nM and SI of 7.4 for GSK3α . GSK3β-IN-4 reduces tau phosphorylation at Ser396 by inhibiting GSK3β and imoroves cognitive deficits in Alzheimer's disease models. GSK3β-IN-4 can be used for the research of Alzheimer's disease.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Alzheimer's Disease | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > GSK-3 | Products > Signaling Pathways > Tau Protein

Product Information

• Catalog No.: HY-179723
• CAS No.: 3083425-61-7
• Molecular Formula: C26H26N4O2
• Molecular Weight: 426.51
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source