INVA8001

Overview

INVA8001 (ASB17061) is a highly selective and orally active chymase inhibitor with IC 50 values for human chymase and mouse mast cell proteinase 4 ( mMCP-4 ) of 0.02 and 0.03 μM, respectively. INVA8001 exhibits IC 50 values for bovine α-chymotrypsin and human cathesin G of 3.4 and 32.1 μM, respectively, and it shows over 1000-fold selectivity for other related serine proteases. INVA8001 inhibits mast cells in a mouse primary sclerosing cholangitis (PSC) model, improves bile duct pathology, and alleviates bile stasis, demonstrating anti-inflammatory and anti-fibrotic effects.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Digestive System Inflammation | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Proteasome

Product Information

• Catalog No.: HY-180131
• CAS No.: 1312993-34-2
• Molecular Formula: C29H38ClN5O8
• Molecular Weight: 620.09
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source