PROTAC AURKA degrader 2

Overview

PROTAC AURKA degrader 2 (compound D) is a potent and selective PROTAC AURKA degrader with an IC 50 of 3.58 nM. PROTAC AURKA degrader 2 exhibits 21.6-fold selectivity for AURKA over AURKB ( IC 50 = 77.2 nM). PROTAC AURKA degrader 2 specifically depletes AURKA on the mitotic spindle. (Pink: Aurora A ligand ( HY-10971 ); Blue: Cereblon ligand ( HY-41547 ); Black: linker ( HY-W008352 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Aurora Kinase

Product Information

• Catalog No.: HY-180132
• CAS No.: 3093582-13-6
• Molecular Formula: C50H50ClFN8O11
• Molecular Weight: 993.43
• Purity: 98.36%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (2.52 mM); Clear solution
• Availability: In-stock

Source

Original product source