VU6052254

Overview

VU6052254, a derivative of VU0467319 ( HY-173396 ), is a selective, potent, orally active and brain-penetrant muscarinic M1 acetylcholine receptor ( mAChR1 ) positive allosteric modulator with an EC 50 of 59 nM. VU6052254 has no activity on the M2-5 receptor ( EC 50 > 30 μM). VU6052254 can improve memory recognition ability and reverse the cognitive impairment induced by Scopolamine (HY-N0296) with minimum effective dose both of 1 mg/kg. VU6052254 can be used for the research of neurological disease , such as Alzheimer's disease.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Alzheimer's Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Others | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > mAChR | Products > Signaling Pathways > Drug Derivative

Product Information

• Catalog No.: HY-180143
• CAS No.: 3035701-02-8
• Molecular Formula: C25H22F2N4O2
• Molecular Weight: 448.46
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source