Keap1/Nrf2/ARE activator 2

Overview

Keap1/Nrf2/ARE activator 2 is an activator of Keap1/Nrf2/ARE pathway and non-competitively inhibits AChE with an IC 50 of 14.79 μM and a K i of 1.35 μM. Keap1/Nrf2/ARE activator 2 promotes Nrf2 nuclear translocation, leading to antioxidant gene upregulation and enhanced cellular defense against oxidative stress. Keap1/Nrf2/ARE activator exhibits robust neuroprotection against both H 2 O 2 - and Scopolamine (SCA) (HY-N0296)-induced injury in PC12 cells. Keap1/Nrf2/ARE activator 2 ameliorates memory impairment and the neuro-inflammation associated with SCA-initiated cognitive dysfunction in a zebrafish model. Keap1/Nrf2/ARE activator 2 can be used for the research of Alzheimer's disease.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Alzheimer's Disease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > TNF Receptor | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > Heme Oxygenase (HO) | Products > Signaling Pathways > Quinone Reductase | Products > Signaling Pathways > Keap1-Nrf2 | Products > Signaling Pathways > Cholinesterase (ChE) | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-180155
• CAS No.: 3105470-83-2
• Molecular Formula: C15H9BrO4
• Molecular Weight: 333.13
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source