Nitromemantine

Overview

Nitromemantine (NitroSynapsin) is a nitrate derivative of Memantine ( HY-B0591 ) and is a dual-functional NMDAR antagonist. Nitromemantine exhibits significant efficacy in rodent models of cerebral infarction through a dual mechanism of blocking channels and regulating receptors via NO/redox regulation. Nitromemantine can target ischemic neurons under hypoxic conditions and enhance its activity. Nitromemantine inhibits the current induced by NMDA, with its IC 50 being 2.4 μM. Nitromemantine can be used for the study of cerebral ischemic stroke.

Application

Products | Products > Disease Areas > Ischemic Stroke | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Cerebrovascular Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Others | Products > Research Areas > Neurological Disease | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > iGluR | Products > Signaling Pathways > Drug Derivative

Product Information

• Catalog No.: HY-180370
• CAS No.: 765890-91-3
• Molecular Formula: C14H24N2O3
• Molecular Weight: 268.35
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source