PAM-2

Overview

PAM-2 is a potent, orally active, CNS-penetrant selective α7 nAChR positive allosteric modulator ( human α7 nAChR EC 50 : 39 μM, rat α7 nAChR EC 50 : 12 μM) with anti-nociceptive and anti-inflammatory activity. PAM-2 exhibits selectivity over α9α10 nAChR ( IC 50 = 174 μM) and Ca V 2.2 channel ( IC 50 = 89 μM). PAM-2 decreases Streptozotocin (STZ) ( HY-13753 )- and Oxaliplatin ( HY-17371 )-inducned nuroparhic pain in mice by α7 nAChR potentiation. PAM-2 can be used for the research of neuropathic pain.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Pain | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > nAChR | Products > Signaling Pathways > Calcium Channel

Product Information

• Catalog No.: HY-180400
• CAS No.: 1426293-61-9
• Molecular Formula: C14H13NO2
• Molecular Weight: 227.26
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source