NPY Y2 antagonist 2

Overview

NPY Y2 antagonist 2 is a modulator targeting the neuropeptide Y (NPY) receptor Y2 , with pK i values of 6.8 nM and 7.2 nM in human and rat brains, respectively, and demonstrating blood-brain barrier penetration . NPY Y2 antagonist 2 shows selectivity for the Y1 and Y5 receptors . NPY Y2 antagonist 2 blocks the negative feedback regulation mediated by the NPY Y2 receptor , thereby increasing endogenous NPY release and enhancing Y1 receptor activation, resulting in the modulation of central neurotransmitter release. NPY Y2 antagonist 2 exhibits moderate in vivo clearance, high free fraction in rat brain, and a favorable brain/plasma ratio and brain exposure. NPY Y2 antagonist 2 is applicable for research in conditions such as mood disorders, anxiety induced by alcohol withdrawal, and social anxiety associated with nicotine withdrawal.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Anxiety or Fear-Related Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Neuropeptide Y Receptor

Product Information

• Catalog No.: HY-180406
• CAS No.: 1262495-12-4
• Molecular Formula: C27H33ClF3N5O
• Molecular Weight: 536.04
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source