SCPI-1 is a potent and competitive mosquito sterol carrier protein-2 ( SCP-2 ) inhibitor ( AeSCP-2 IC 50 = 0.347 µM; AeSCP-x IC 50 = 0.527 µM). SCPI-1 exhibits physiological effects on cholesterol metabolism in cultured insect cells ( IC 50 of 5.53 µM in Aag-2 cells). SCPI-1 shows insecticidal activity against Aedes aegypti with a LD 50 of 4.8 µM.
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