CAI0019 is an orally active α-carbonic anhydrase inhibitor based on the Acetazolamide ( HY-B0782 ) framework. CAI0019 exhibits narrow-spectrum antibiofilm activity, with its MIC 50 being 0.094 μM and MIC 90 being 0.39 μM. CAI0019 selectively inhibits Enterococcus in a septic peritonitis mouse model, without affecting most intestinal commensal bacteria.
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