IRAK4-IN-33

Overview

IRAK4-IN-33 (Compound 22) is a selective, potent and orally active interleukin-1 receptor-associated kinase 4 ( IRAK4 ) inhibitor with an IC 50 0.36 nM. IRAK4-IN-33 can block the pro-inflammatory signaling pathway mediated by IRAK4 and inhibit the release of TNFα and IFNα . IRAK4-IN-33 shows weak inhibition for hERG channel ( IC 50 > 30 μM). IRAK4-IN-33 can be used for the research of inflammation and immunology, such as rheumatoid arthritis.

Application

Products | Products > Disease Areas > Arthritis | Products > Disease Areas > Rheumatoid Arthritis | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Autoimmune Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > IRAK | Products > Signaling Pathways > TNF Receptor | Products > Signaling Pathways > IFNAR

Product Information

• Catalog No.: HY-180579
• CAS No.: 2411497-72-6
• Molecular Formula: C27H26N10OS
• Molecular Weight: 538.63
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source