GRK5-IN-5

Overview

GRK5-IN-5 (Compound 4a) is a selective G protein-coupled receptor (GPCR) kinase 5 ( GRK5 ) inhibitor with an IC 50 of 0.03 μM. GRK5-IN-5 shows IC 50 values of 2.2 and 0.036 μM for GRK2 and GRK6. GRK5-IN-5 has potent anti-myocardial hypertrophy activity and also inhibits the proliferation of non-myocardial cells. GRK5-IN-5 can inhibit the abnormal upregulation of hypertrophy marker genes Nppa and Nppb, thus blocking pathological myocardial remodeling. GRK5-IN-5 can be used for the research of cardiac hypertrophy.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Heart Disease | Products > Disease Areas > Cardiomyopathy | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > G Protein-coupled Receptor Kinase (GRK)

Product Information

• Catalog No.: HY-180583
• CAS No.: 3061801-11-1
• Molecular Formula: C30H27FN4O5
• Molecular Weight: 542.56
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source