ML252 hydrochloride

Overview

ML252 hydrochloride is a selective inhibitor of KCNQ2 (Kv7.2) channel with IC 50 s of 69 nM, 2.92 μM, 0.12 μM and 0.20 μM for KCNQ2, KCNQ1 (Kv7.1), KCNQ2/Q3 and KCNQ4, respectively. ML252 hydrochloride also inhibits Cytochrome P450 with IC 50 s of 6.1 nM ( CYP1A2 ), 18.9 nM ( CYP2C9 ), 3.9 nM ( CYP3A4 ), 19.9 nM ( CYP2D6 ), respectively. ML252 hydrochloride shows highly brain penetrant.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Potassium Channel | Products > Signaling Pathways > Cytochrome P450

Product Information

• Catalog No.: HY-18063A
• CAS No.: 2309887-61-2
• Molecular Formula: C20H25ClN2O
• Molecular Weight: 344.88
• Purity: 99.98%
• Storage: -20°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Availability: In-stock

Source

Original product source