JWZ-8-103

Overview

JWZ-8-103 is an orally active PRLX-93936 ( HY-119264 ) analog and TRIM21 -targeting molecular glue . JWZ-8-103 increases the thermal stability of TRIM21 . JWZ-8-103 promotes a robust and rapid interaction between TRIM21 and NUP98 (apparent EC 50 = ∼20 μM for TRIM21 PRYSPRY and NUP98 APD). JWZ-8-103 has anti-cancer effects against pancreatic cancer .

Application

Products | Products > Disease Areas > Pancreatic Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Others | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Molecular Glues | Products > Signaling Pathways > Drug Derivative | Products > Signaling Pathways > E1/E2/E3 Enzyme

Product Information

• Catalog No.: HY-180654
• CAS No.: 3110272-60-8
• Molecular Formula: C21H22ClFN4O2
• Molecular Weight: 416.88
• Purity: 98.04%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (6.00 mM); Clear solution
• Availability: In-stock

Source

Original product source