BI-9627

Overview

BI-9627, a chemical probe, is a potent sodium-hydrogen exchanger isoform 1 ( NHE1 ) inhibitor ( IC 50 = 6 and 31 nM in intracellular pH recovery (pH i ) and human platelet swelling assays). BI-9627 displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 decreases autophagy in HTR-8/SVneo cells. BI-9627 can significantly reduce the pH i of human sperm and partially reverse the effect of DMA. BI-9627 prolongs Ca 2+ recovery time in KO hiPSC-CMs. BI-9627 shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Cardiovascular Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Autophagy | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Na+/H+ Exchanger (NHE) | Products > Signaling Pathways > Autophagy

Product Information

• Catalog No.: HY-18071
• CAS No.: 1204329-34-9
• Molecular Formula: C16H19F3N4O2
• Molecular Weight: 356.34
• Purity: 99.71%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.08 mg/mL (5.84 mM); Clear solution
• Availability: In-stock

Source

Original product source