Cathepsin L-IN-6 (Compound 6a) is a selective cathepsin L inhibitor with an IC 50 of 0.021 μM. Cathepsin L-IN-6 suppresses cathepsin L activity by directly binding to cathepsin L . Cathepsin L-IN-6 inhibits IL-6 and IL-8 . Cathepsin L-IN-6 shows a high anti-inflammatory activity. Cathepsin L-IN-6 can be used in the research of acute lung injury.
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