E8431

Overview

E8431 is a DCSTAMP antagonist. DCSTAMP is a key fusion protein that coordinates cell-cell fusion during osteoclastogenesis. E8431 inhibits the cytoskeleton reorganization mediated by the RAP1B-RAC1 signaling pathway. E8431 has the ability to inhibit pre-fusion of osteoclasts and, while inhibiting bone resorption, stimulates the secretion of PDGFBB , thereby stimulating the process of bone and blood vessel formation. E8431 effectively reduces bone loss in a mouse model caused by ovariectomy. E8431 can be used for the study of osteoporosis.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Mineral Metabolism | Products > Disease Areas > Osteoporosis | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > PDGFR | Products > Signaling Pathways > Ras

Product Information

• Catalog No.: HY-180801
• CAS No.: 2419580-01-9
• Molecular Formula: C24H26N2O3
• Molecular Weight: 390.47
• Purity: 97.34%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source