RIPK1-IN-39

Overview

RIPK1-IN-39 (compound 2) is a potent and selective RIPK1 inhibitor ( IC 50 = 69.40 nM) exhibiting >100-fold selectivity over RIPK3 ( IC 50 = 6946 nM). RIPK1-IN-39 protects HT-22 and HT-29 cells from necroptosis by inhibiting the phosphorylation and activation of the RIPK1-RIPK3-MLKL pathway. RIPK1-IN-39 demonstrates neuroprotective effects in a rat model of middle cerebral artery occlusion (MCAO). RIPK1-IN-39 can be used for acute ischemic stroke (AIS) research.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Cerebrovascular Disease | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Neurological Disease | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > RIP kinase | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-180806
• CAS No.: 3065634-42-3
• Molecular Formula: C29H24FN5O2S
• Molecular Weight: 525.60
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source