NLRP3-IN-86

Overview

NLRP3-IN-86 (Compound 8a), a derivative of Songorine ( HY-N2080 ), is a potent and selective NLRP3 inflammasome inhibitor. NLRP3-IN-86 can reduce LPS ( HY-D1056 )- and Nigericin ( HY-127019 )-stimulated lactate dehydrogenase ( LDH ) release ( IC 50 = 2.69 μM in THP-1 cells and 1.75 μ M in J774A.1 cells). NLRP3-IN-86 can inhibit gasdermin D (GSDMD) cleavage and IL-1β secretion. NLRP3-IN-86 can inhibit cell pyroptosis . NLRP3-IN-86 can be used for research of inflammation.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > NOD-like Receptor (NLR) | Products > Signaling Pathways > Lactate Dehydrogenase | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > Pyroptosis

Product Information

• Catalog No.: HY-180830
• CAS No.: 2361570-54-7
• Molecular Formula: C22H29NO3
• Molecular Weight: 355.47
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source