GS-1291269

Overview

GS-1291269 is a potent and neutral ketohexokinase ( KHK ) inhibitor, with IC 50 s of 0.38 and 2.1 nM against KHK-C and KHK-A , respectively. GS-1291269 demonstrates liver and kidney fructose-1-phosphate (F1P) reduction in a fructose challenge model in rats. GS-1291269 can be used for kidney disease and metabolic-dysfunction-associated steatotic liver disease (MASLD) research.

Application

Products | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Liver Disease | Products > Disease Areas > Renal Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Endocrinology | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > Ketohexokinase

Product Information

• Catalog No.: HY-180921
• CAS No.: 2845278-33-1
• Molecular Formula: C20H19F5N4O2S
• Molecular Weight: 474.45
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source