Leu-PEG1-Dasa

Overview

Leu-PEG1-Dasa is a potent BCR-ABL PROTAC degrader with a DC 50 of 0.48 nM. Leu-PEG1-Dasa uses a single amino acid as the E3 ligand and belongs to a mini-PROTAC, functioning through the N-terminal canonical pathway. Leu-PEG1-Dasa exhibits potent anti-proliferative activity against K562 cells. Leu-PEG1-Dasa can be used for the study of chronic myeloid leukemia (CML). (Pink: Bcr-Abl ligand ( HY-10181 ); Blue: Ligands for E3 Ligase ligand ( HY-N0486 ); Black: linker).

Application

Products | Products > Disease Areas > Chronic Myelogenous Leukemia | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Bcr-Abl

Product Information

• Catalog No.: HY-180925
• CAS No.: 3037776-72-7
• Molecular Formula: C33H46ClN9O5S
• Molecular Weight: 716.29
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source