BE2012

Overview

BE2012, SR8278 ( HY-14415 ) derivative, is a potent and selective REV-ERBα/β Antagonist with EC 50 values of 0.285 and 0.346 μM. BE2012 binds to the ligand-binding domain (LBD) of REV-ERB , preventing the receptor from recruiting co-inhibitory factors and thereby releasing the transcriptional repression on downstream target genes. BE2012 can upregulate the expression of myogenic transcription factors Myf5 and Myod, promoting muscle regeneration and repair in acute muscle injury micemodels.

Application

Products | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Muscle Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > REV-ERB

Product Information

• Catalog No.: HY-180944
• CAS No.: 667889-47-6
• Molecular Formula: C18H19N3O
• Molecular Weight: 293.36
• Purity: 99.49%
• Storage: 4°C, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
• Availability: In-stock

Source

Original product source