Gly-PEG3-BA

Overview

Gly-PEG3-BA is an EML4-ALK PROTAC degrader. Gly-PEG3-BA effectively reduces EML4-ALK with a DC 50 value of 0.50 μM in H3122 ( EML4-ALK ) cells. Gly-PEG3-BA effectively reduces EGFR mutant (L858R/T790M) levels with a DC 50 of 20.15 μM in H1975 (EGER-L858R/T790M) cells. Gly-PEG3-BA exerts potent antiproliferation activity in H3122 ( EML4-ALK ) and H1975 ( EGER -L858R/T790M) cells with IC 50 s value of 0.84 and 20.74 μM. Gly-PEG3-BA can be used for non-small lung cancer research. (Pink: EGFR and EML4-ALK ligand ( HY-150908 ); Blue: Ligands for E3 Ligase ligand ( HY-Y0966 ); Black: linker ( HY-W040165 )).

Application

Products | Products > Disease Areas > Respiratory Cancer | Products > Disease Areas > Non-Small Cell Lung Cancer | Products > Disease Areas > Cancer | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Lung Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > JAK/STAT Signaling | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > EGFR

Product Information

• Catalog No.: HY-180966
• CAS No.: 3057939-66-6
• Molecular Formula: C34H48ClN8O7P
• Molecular Weight: 747.22
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source